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Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics)

reference: CD genimics, Genom-Wide Profiling of Histone Modifications with ChIP-Seq
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Introduction to Histone Modifications

There are at least 9 different types of post-translational modifications (PTM) have been found.

Examples of Modeification Functions of PTM
methylation
acetylation
phosphorylation
ubiquitylation
sumoylation		 Change chromatin structures
Recruit histone modifiers
change in gene expression
Transcriptional regulation
chromosome packaging
DNA damage/repair

Major Types of Modification

1. Methylation

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图1

2. Acetylation

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图2

3. Phosphorylation

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图3

4. Ubiquitylation

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图4

ubiquitin moiety (76-amino-acid peptide.)

5. Sumoylation

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图5

CHIP-SEQ DATA ANALYSIS

Genome-Wide Profiling of Histone Modification with Chip-Seq (CD Genomics) - 图6

Enjoy~

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